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After receiving a thumping in the first leg, Dortmund will hope they can salvage some pride when they welcome big-timers Barcelona to their home turf. Here are predictions, team news, betting tips, and possible line-ups for the game.
Barcelona showed their class against Dortmund in the first leg, securing a comfortable 4-0 victory to give themselves a solid cushion ahead of the trip to Germany.
It was a night for Raphinha, who matched Lionel Messi's club record of 19 goal involvements in a single Champions League season (19).
The Catalan side maintained their lead at the top of the La Liga table with a 1-0 victory away at Leganes last weekend.
Dortmund reached the final of the UCL last season and would have been hoping to take it one step further this year.
However, except they can match the type of remontada Barcelona pulled off against PSG in 2016-17, they can kiss that dream goodbye.
BVB held Bayern Munich to a 2-2 draw in the Bundesliga last weekend in what has been a poor league season by their standards.
PAY ATTENTION: Check out Bet Of The Day page - we provide expert tips
Borussia Dortmund vs Barcelona Head to Head
Dortmund are not only looking to match the greatest comeback in UCL history, but they are also hoping for a first-ever win against Barcelona.
In six meetings, the German side has lost four times and drawn twice. Failure to win on Tuesday will see them match their worst run of seven matches without a win against a team in Europe, suffered between 1966 and 1999 against Rangers.
Borussia Dortmund vs Barcelona Team News and Possible Lineups
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Dortmund will remain without Marcel Sabitzer and Nico Schlotterbeck due to the injuries, with the latter still several months away from reaching full fitness.
However, the hosts will welcome back Pascal Gross, who missed the first leg due to suspension.
Barcelona suffered a big blow in the win over Leganes, as left back Alejandro Balde sustained a hamstring injury and is expected to be sidelined until the end of the month.
The trio of Marc Bernal, Marc-André ter Stegen and Marc Casado all remain sidelined with knee injuries, while Dani Olmo is also out with an adductor problem.
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Borussia Dortmund Predicted lineup (4-2-3-1)
Kobel (GK); Ryerson, Can, Anton, Bensebaini; Gross, Nmecha; Gittens, Brandt, Adeyemi; Guirassy
Barcelona Predicted lineup (4-2-3-1)
Szczesny (GK); Kounde, Araujo, Cubarsi, Martin; Pedri, De Jong; Yamal, Lopez, Raphinha; Lewandowski
Borussia Dortmund vs Barcelona Predictions & Betting Tips
Dortmund will be hoping to at least record a first-ever win over Barcelona, but we do not see that happening.
The hosts have been fragile in defence all season, and they lack the attack to outwit the visitors. It is likely that Barcelona will record a win here once again.
Over 2.5
Over 2.5 cards
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