The England international took to social media to express his disappointment.
Manchester United left-back Luke Shaw has suffered another injury setback, just weeks after returning to action.
Shaw's injury woes have been persistent this season, missing the start of the campaign due to a calf injury and was sidelined for nearly four months earlier in the year.
His recent return to the team offered a glimmer of hope, but this latest setback is a big blow for United.
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The England international took to social media to express his disappointment, revealing that he had picked up a new injury during training.
"I've been through a lot of ups and downs but this has definitely been my toughest period," Shaw wrote on Instagram.
"I'm absolutely devastated and it's extremely tough to come to terms with reality at this moment in time."
The 29-year-old's absence will further weaken United's defensive options, particularly as they prepare to face Arsenal in an important Premier League clash on Wednesday.