If the pair fails to make the lineup, it will be a huge blow for Vipers, who want to overcome a two-goal deficit against the Botswana outfit.
Vipers SC are racing against time to have two of their most essential defenders recover from injury setbacks ahead of their CAF Champions League crunch tie with Jwaneng Galaxy.
Hilary Mukundane and Patrick Mbowa are major doubts for the Venoms for Saturday night's game at St Mary's Stadium, Kitende.
"Hilary Mukundane and Patrick Mbowa are doubtful after suffering a knock on the knee and acute achilles tendon respectively in our last encounter," a Vipers' communication.
If the pair fails to make the lineup, it will be a huge blow for Vipers, who want to overcome a two-goal deficit against the Botswana outfit.
While they will need to score at least three goals, the Venoms must also make sure they don't concede.
Mukundane and Mbowa started the game in Botswana, with the former playing 90 minutes while the latter was withdrawn late in the second half.
Despite being a natural central defender, Mbowa, who joined Vipers in the ongoing transfer window, has operated as a holding midfielder in the past two games.