As the two remain sidelined, Casemiro can feature for the Red Devils.
Manchester United manager Erik ten Hag has confirmed that Alejandro Garnacho and Luke Shaw will not be available for the Europa League clash against Sevilla.
The two will join Marcus Rashford on the list of unavailable players for the quarter-final clash set for Thursday. Rashford – with 28 goals so far this season – will be absent following a muscle injury.
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The in-form forward will be sidelined after he picked up a late injury in the last match.
"No, [they are] both not available," Ten Hag told reporters when asked about Garanacho and Shaw’s availability.
"Definitely, the injury of Garnacho is more severe, is stronger, but with Luke Shaw, I expect him back at short notice, yes."
Although United have welcomed both Anthony Martial and Christian Eriksen back into action, Shaw’s absence makes Ten Hag’s defensive choices thin with crucial games lying ahead.
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The youngster hopes to return and become a regular player under the Dutchman.
The England fullback was not available for the match against Everton – which United won 2-0 at Old Trafford – after he was withdrawn in the first half of last Wednesday's win over Brentford.
The manager, however, did not reveal the nature of Shaw’s injury, but it is not expected to be too serious.
On the other hand, Garnacho is expected to be a long-term absentee, as the Argentine is suffering from an ankle injury he picked up during March's goalless draw against Southampton.