He assumed interim managerial duties after Antonio Conte was sacked in late March.
Tottenham Hotspur have sacked Cristian Stellini following Sunday’s Premier League humiliation by Newcastle United.
Spurs were beaten 6-1 by the Magpies, and a day after the embarrassing result, the board, led by chairman Daniel Levy, has decided to part ways with the Italian.
"Sunday’s performance against Newcastle was wholly unacceptable," the club announced on Monday.
"It was devastating to see. We can look at many reasons why it happened and whilst myself, the board, the coaches and players must all take collective responsibility, ultimately the responsibility is mine.
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"Cristian will leave his current role along with his coaching staff. Cristian stepped in at a difficult point in our season and I want to thank him for the professional manner in which he and his coaching staff have conducted themselves during such a challenging time.
"We wish him and his staff well."
Ryan Mason will guide the club in the remaining matches; "Ryan Mason will take over head coach duties with immediate effect. Ryan knows the club and the players well. We shall update further on his coaching staff in due course," Spurs added.
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"I met with the player committee today - the squad is determined to pull together to ensure the strongest possible finish to the season. We are all clear we need to deliver performances that earn your amazing support."
Mason was overlooked for the interim position after the club sacked Conte on March 26, and Stellini was preferred instead.
Mason was in caretaker charge for the final weeks of the 2020–21 season after Jose Mourinho was sacked, and he went on to win four of six league games.
His next game will be a Premier League match against Manchester United on Thursday.