The Venoms, who lost 3-1 in the first half of the campaign to the Kasasiro Boys are expected to retaliate in front of their fans.
Reigning Uganda Premier League champions Vipers SC are breathing revenge as they play host to nemesis KCCA FC in the Uganda Premier League under the St Mary's Stadium, Kitende floodlights on Friday.
The Venoms, who lost 3-1 in the first half of the campaign to the Kasasiro Boys are expected to retaliate in front of their fans.
"It’s a big, big game, we need the three points and revenge as well, especially at home," Vipers deputy captain Ashraf Mandela was quoted by the club media.
The two will renew acquaintances with the Venoms chasing a third successive title, while KCCA are aiming at ascending further up on the table.
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KCCA head coach Abdallah Mubiru conceded they will miss their main talisman but also asserted the other players would step up for the challenge.
"We have to continue the run and keep tabs on those ahead of us at the moment. I’m really looking forward to playing this game," Mandela noted.
Vipers sit fourth on the log with 35 points, eight behind leaders Kitara FC, who have played three games more.
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The bout will also present the two most successful sides in the last decade. Vipers and KCCA have managed five and four UPL titles, respectively, over the last ten seasons.
On the other hand, KCCA are 10th on the 16-team table with 26 points in 20 games played.
“It will be a very, very tough game. It will be a very intense game but, for me, we have to be us - to be exactly how we want to play," said Mandela.
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The tie presents two of the country's most successful sides across the past decade, as Vipers have won five league titles, with KCCA on four in that spell. Express FC is the only other team to have a sniff.
"We have to be focused 100 per cent, we want to win and we will go for it. This is our mentality.”
Vipers lost 3-1 in the first round when they visited the MTN Omondi Stadium, Lugogo courtesy of Muhammad Shaban's brace and one from Usama Arafat. Abubakar Lawal netted their consolation.
However, Shaban and Arafat are ruled out due to suspension and national team engagements, respectively.
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Goals from Denis Omedi, Jude Semugabi and Living Kabon ensured that the Royals took their tally to 43 points, four ahead of runners-up BUL FC, who have played a game less.
Vipers and KCCA will be meeting for the 38th time in the league history, and the former hold the majority of victories.
Tomorrow's hosts have accumulated 15 wins in this fixture, and managed nine draws, while KCCA have netted 13 wins.